e/Dideoxynucleotides

Information
has gloss	eng: Dideoxynucleotides, or ddNTPs, are nucleotides lacking a 3-hydroxyl (-OH) group on their deoxyribose sugar. Since deoxyribose already lacks a 2-OH, dideoxyribose lacks hydroxyl groups at both its 2 and 3 carbons. The lack of this hydroxyl group means that, after being added by a DNA polymerase to a growing nucleotide chain, no further nucleotides can be added as no phosphodiester bond can be created based on the fact that deoxyribonucleoside triphosphates (which are the building blocks of DNA) allow DNA chain synthesis to occur through a condensation reaction between the 5 phosphate (following the cleavage of pyrophospate) of the current nucleotide with the 3 hydroxyl group of the previous nucleotide. The dideoxyribonucleotides do not have a 3' hydroxyl group, hence no further chain elongation can occur once this dideoxynucleotide is on the chain. This can lead to the determination of the DNA sequence. Thus, these molecules form the basis of the dideoxy chain-termination method of DNA sequencing, which was developed by Frederick Sanger in 1977.
lexicalization	eng: Dideoxynucleotides
instance of	(noun) a phosphoric ester of a nucleoside; the basic structural unit of nucleic acids (DNA or RNA) base, nucleotide

Meaning
Czech
has gloss	ces: Dideoxyribonukleotid (ddNTP) je derivát nukleotidů, který postrádá OH skupinu na 2 i 3 uhlíku svého cukru (dideoxy)ribózy. Zatímco totiž má ribonukleotid obě OH skupiny a deoxyribonukleotid jednu OH skupinu, dideoxynukleotid neobsahuje žádnou. Dideoxynukleotidy jako takové jsou pouze uměle připravené, nejsou schopné plnit správně funkci v buňce. Mají však pro výzkumníky význam např. v DNA sekvenování metodou Fredericka Sangera, neboť jsou schopné ukončit probíhající replikaci DNA.
lexicalization	ces: Dideoxyribonukleotid
German
has gloss	deu: Didesoxyribonukleosid-Triphosphate (ddNTP) sind artifizielle DNA-Nukleotide, die bei der DNA-Sequenzierung nach Sanger Verwendung finden. Die ddNTPs sind wie die Desoxyribonukleosid-Triphosphate (dNTPs) aufgebaut. Allerdings ist die Ribose (Zucker) an Position 2 und 3 desoxidiert. Dadurch fehlt am 3'-Kohlenstoff-Atom die Hydroxylgruppe, an der bei der Polymerisation das nächste Nukleotid angehängt wird.
lexicalization	deu: Didesoxyribonukleosid-Triphosphate
lexicalization	deu: Didesoxyribonukleosidtriphosphate
Castilian
has gloss	spa: Los didesoxinucleótidos (abreviados como ddNTP) son nucleótidos que carecen de un grupo 3'-hidroxilo (-OH) en la desoxirribosa.
lexicalization	spa: Didesoxinucleotido
lexicalization	spa: Didesoxinucleótido

Media
media:img	DNA Sequencin 3 labeling methods.jpg