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has gloss | eng: Hemoglobin E or haemoglobin E (HbE) is an abnormal hemoglobin with a single point mutation in the β chain. At position 26 there is a change from a glutamate to a lysine. People with the hemoglobin E trait have a mild hemolytic anemia and mild splenomegaly. Hemoglobin E trait is asymptomatic. In combination with certain thalassemia mutations, it provides an increased resistance to malaria (P. falciparum). Hemoglobin E is most prevalent in Southeast Asia (Thailand, Indonesia, Bangladesh, Vietnam ) and North-East India, where in certain areas carrier rates reach 60% of the population. The mutation is estimated to have arisen within the last 5,000 years . |
lexicalization | eng: Hemoglobin E |
instance of | e/Blood proteins |
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