e/LIN28

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has glosseng: Lin-28 homolog A is a protein that in humans is encoded by the LIN28 gene. It is marker of undifferentiated human embryonic stem cells and has been used to enhance the efficiency of the formation of induced pluripotent stem (iPS) cells from human fibroblasts. It encodes a cytoplasmic mRNA-binding protein that binds to and enhances the translation of the Igf2 mRNA. . Lin28 has also been shown to bind to the let-7 pre-miRNA and block production of the mature let-7 microRNA in mouse embryonic stem cells .
lexicalizationeng: LIN28
instance of(noun) (genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors"
factor, gene, cistron
Meaning
German
has glossdeu: lin-28 (auch lin28) ist ein Entwicklungsgen, das in den Zellen der meisten vielzelligen Tiere vorkommt. Seine Position im Humangenom ist auf Chromosom 1, Location 1p36.11. Das Proteinprodukt von lin-28 ist ein evolutionär hoch konserviertes, RNA-bindendes Protein, das durch microRNAs reguliert wird und eine Bedeutung in der zeitlichen Steuerung der Embryonalentwicklung von Caenorhabditis elegans hat . Der Name für das Gen kommt aus dem Englischen und steht für "cell lineage abnormal 28" ("abnormale Zellabstammung 28").
lexicalizationdeu: lin-28
Russian
has glossrus: Lin28 (также Lin-28) — ген, встречающийся в геномах животных. В геноме человека расположен на первой хромосоме, локализуется 1p36.11.
lexicalizationrus: Lin28

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