Information | |
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has gloss | eng: A locked nucleic acid (LNA), often referred to as inaccessible RNA, is a modified RNA nucleotide. The ribose moiety of an LNA nucleotide is modified with an extra bridge connecting the 2 oxygen and 4 carbon. The bridge "locks" the ribose in the 3'-endo (North) conformation, which is often found in the A-form of DNA or RNA. LNA nucleotides can be mixed with DNA or RNA bases in the oligonucleotide whenever desired. Such oligomers are commercially available. The locked ribose conformation enhances base stacking and backbone pre-organization. This significantly increases the thermal stability (melting temperature) of oligonucleotides. |
lexicalization | eng: locked nucleic acid |
instance of | (noun) (biochemistry) any of various macromolecules composed of nucleotide chains that are vital constituents of all living cells nucleic acid |
Meaning | |
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German | |
has gloss | deu: LNA (engl. locked nucleic acid) sind verbrückte Nukleinsäuren, in welchen der Zucker-Anteil chemisch modifiziert ist. |
lexicalization | deu: LNA |
Chinese | |
has gloss | zho: 鎖核酸(Locked nucleic acid,LNA)是一種經過修飾的RNA,LNA中一部分核糖上的2與4碳連結在一起。一般可見於A-DNA或RNA。 |
lexicalization | zho: 鎖核酸 |
Media | |
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media:img | LNA 3'-endo num.svg |
media:img | LNA-Monomer.svg |
media:img | LNA.gif |
media:img | LockedNucleicAcid(LNA).gif |
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