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| has gloss | eng: Urotensin-II (U-II) is a peptide ligand, initially isolated from the neurosecretory system of the Goby fish (Gillichthys mirabilis) . For many years it was thought that U-II does not exhibit significant effects in mammalian systems; a view quickly overturned when it was demonstrated that Goby U-II produces slow relaxation of mouse annococygeus muscle, in addition to contraction of rat artery segments. In 1998, the cDNA encoding a U-II precursor was cloned in humans, unequivocally demonstrating its existence in mammalian species. |
| lexicalization | eng: Urotensin-II |
| instance of | (noun) amide combining the amino group of one amino acid with the carboxyl group of another; usually obtained by partial hydrolysis of protein peptide |
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