e/A431 cells

Information
has gloss	eng: A431 cells are a model cell line (epidermoid carcinoma) used in biomedical research. More specifically, they are used in studies of the cell cycle and cancer-associated cell signalling pathways since they express abnormally high levels of the Epidermal growth factor receptor (EGFR). As such they are often used as a positive control for EGFR expression. They contain no functional p53, a potent tumor suppressor gene, and so are highly sensitive to mitogenic stimuli. A431 cells were established from an epidermoid carcinoma in the vulva of an 85 year old female patient.
lexicalization	eng: A431 Cells
instance of	c/Cell lines