| Information | |
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| has gloss | eng: Cyclic peptides (or cyclic proteins) are polypeptide chains whose amino and carboxyl termini are themselves linked together with a peptide bond, forming a circular chain. A number of cyclic peptides have been discovered in nature and they can range anywhere from just a few amino acids in length to hundreds. The processes by which cyclic peptides are formed in cells are not yet fully understood. One interesting property of cyclic peptides is that they tend to be extremely resistant to digestion, allowing them to survive intact in the human digestive tract. This trait makes cyclic peptides attractive to protein based drug designers for use as scaffolds which, in theory, could be engineered to incorporate any arbitrary protein domain of medicinal value, in order to allow those components to be delivered orally. |
| lexicalization | eng: cyclic peptide |
| instance of | (noun) amide combining the amino group of one amino acid with the carboxyl group of another; usually obtained by partial hydrolysis of protein peptide |
| Meaning | |
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| German | |
| has gloss | deu: Cyclopeptide sind ringförmige Peptide und zugleich Lactame. Zu dieser Verbindungsgruppe zählen Polypeptide, deren Aminosäuresequenz zu einem Ring (oder mehreren Ringen) geschlossen sind. Es gibt auch kettenförmige Peptide (z. B. Keratin, Insulin, Oxytocin), bei denen zwei oder mehr Ketten über mehrere Disulfidbrücken miteinander verbunden sind. Diese Peptide enthalten auch Ringe, zählen im engeren Sinne jedoch nicht zu den Cyclopeptiden. Oft enthalten Cyclopeptide statt der üblichen L-Aminosäuren teilweise D-Aminosäuren oder α-Hydroxycarbonsäuren (Cyclodepsipeptide). Die Cyclodepsipeptide sind zugleich Lactame und Lactone. In der folgenden Abbildung ist links das Cyclodipeptid der Aminosäure Glycin abgebildet: |
| lexicalization | deu: Cyclopeptide |
| Chinese | |
| has gloss | zho: 环肽是一类由氨基酸(包括蛋白质氨基酸和非蛋白质氨基酸)组成的环状化合物。目前发现的环肽含有2-37个残基。环肽通常是由细菌和真菌等低等生物合成,具有广泛的生理活性。在植物中也发现有环肽的存在,但尚未发现植物环肽的生物合成途径。 |
| lexicalization | zho: 环肽 |
| Media | |
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| media:img | Alpha-amanitin-Line-Structure2.png |
| media:img | Bacitracin.svg |
| media:img | Cyclodipeptide and Cyclodepsipeptide.png |
| media:img | Cyclosporine.png |
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