e/Protein Misfolding Cyclic Amplification

Information
has gloss	eng: "PMCA" redirects here. For the transport protein, see Plasma membrane Ca2+ ATPase. Protein Misfolding Cyclic Amplification (PMCA) is an amplification technique (conceptually like PCR but not involving nucleotides) to multiply misfolded prions. It is a test for spongiform encephalopathies like BSE. The technique initially incubates a small amount of abnormal prion with an excess of normal protein, so that some conversion takes place. The growing chain of misfolded protein is then blasted with ultrasound, breaking it down into smaller chains and so rapidly increasing the amount of abnormal protein available to cause conversions. By repeating the cycle, the mass of normal protein is rapidly changed into misfolded prion.
lexicalization	eng: Protein Misfolding Cyclic Amplification
instance of	(noun) (microbiology) an infectious protein particle similar to a virus but lacking nucleic acid; thought to be the agent responsible for scrapie and other degenerative diseases of the nervous system prion

Meaning
German
has gloss	deu: Protein Misfolding Cyclic Amplification (PMCA) ist eine biochemische Technik zur Vervielfältigung von falsch gefalteten Proteinen (Prionen) und wird als Test für Enzephalopathien wie BSE verwendet.
lexicalization	deu: PMCA